Midazolam and diazepam for gastroscopy

Diazepam and midazolam for sedation during bronchoscopy.

Sir,—It is regretted that the interesting paper by Korttila and Tarkkanen (1985) does not state which preparation of diazepam they used. The early relative potency studies of midazolam and diazepam were undertaken with the organic solvent preparation, Valium. A review (Dundee et al., 1984) of these puts the relative potency of the two drugs at about 1.5:2.1:1. However, if Korttila and Tarkkanen...

Intravenous sedation for upper gastrointestinal endoscopy: diazepam versus midazolam.

Diazepam or midazolam for orotracheal intubation in the ICU?

OBJECTIVE to compare clinical and cost effectiveness of midazolam and diazepam for urgent intubation. METHODS patients admitted to the Central ICU of the Santa Casa Hospital Complex in Porto Alegre, over the age of 18 years, undergoing urgent intubation during 6 months were eligible. Patients were randomized in a single-blinded manner to either intravenous diazepam or midazolam. Diazepam was ...

Comparison of the recovery characteristics of diazepam and midazolam.

A double-blind crossover comparison of efficacy and recovery from midazolam 5 mg and diazepam (in propylene glycol) 10 mg was undertaken in eight volunteer subjects. It was found that midazolam was significantly more potent in this dose ratio than diazepam, helping to explain the finding of previous studies that the recovery from midazolam and diazepam in a 1:2 dose ratio is comparable.

Carbon dioxide response curves following midazolam and diazepam.

The ventilatory response to carbon dioxide was measured in volunteers before, and at intervals after the i.v. administration of midazolam 0.075 mg kg-1 and diazepam 0.15 mg kg-1. In the doses used neither drug caused any statistically significant respiratory depression and there were no differences between the drugs.